The "Karen" meme is defined as a label for entitled or demanding women, with the hosts introducing the acronym "SIGN" (Shame, Insult, Guilt, Need to be right). Attributed to YouTube creator Kevin Samuels, SIGN language is described as the primary tactic used by "Karens" and media figures to manipulate public opinion. A throwback clip from the show *Black-ish* is used to illustrate these tactics in a vaccine debate.